They're Coming is an image that originated somewhere on 4chan, likely on /v/, in 2013. The screamer is a comic with a sim waking up with a call asking the sim to not open the house's doors. The caller abruptly hangs up. The rest of the comic shows the sim scared until the last panel where a figure with a knife is shown.
After 5 seconds of viewing the comic, an oversaturated face pops up.
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NOTE: The following GIF contains a screamer!