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Please be advised that the following article contains spoilers for the screamer mentioned in the title or description. If you have not yet experienced the material and wish to avoid spoilers, we recommend that you proceed with caution or refrain from reading until you have done so.
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Regan MacNeil is a character from the 1971 horror novel The Exorcist, its 1973 horror film adaptation with the same name, and its sequel The Heretic. Regan is a 12-year-old girl who gets possessed by the demon Pazuzu (who is also seen in some screamers), making her unable to control her own actions.
Different pictured of Regan are commonly used as images for screamers, with some famous examples including The Maze and Shafou.com as possessed, and as Maze Game 3 appearing eyeless.
Regan MacNeil's role was played by Linda Blair, an American actress.