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From Screamer Wiki
What's Wrong With This Picture?, also called What's Wrong? or What's wrong with this image? is an infamous internet screamer created by Jaybill McCarthy, originally posted to his personal website "Jaybill" in February 2002. Shortly after its release, it gained notoriety and became an example of an early e-mail chainletter prank. The nature of this screamer has inspired Forest-wmv, Where's Waldo, When you see it and many more.
The animation disguises itself as a normal stock photo of a dining room; depicting an open window, table, chairs, paintings, and flowers. The viewer is then asked to find something wrong in it.