Ghost

Ghost is a screamer video uploaded in 2006 by the user zxvvxz.

Video
The video starts by showing an image of a retro looking bedroom with the task of finding a ghost somewhere in it. Of course, there's no ghost to be found. At the 21 second mark, a picture of Mary, mother of Jesus, with bleeding eyes appears with a loud female scream. It then cuts back to the room for the remainder of the video.

Link
NOTE: The following video contains a screamer.

youtube.com/watch?v=uONjEz0oxd4